Article
Toll-like receptors TLR4 (Asp299Gly and Thr399Ile) and TLR2 (Arg677Trp and Arg753Gln) gene polymorphisms in end-stage renal disease patients on peritoneal dialysis.
International urology and nephrology - 1 Dec 2015
Singh Kamini, Prasad Kashi Nath, Mishra Priyanka, Khatoon Jahanarah, Prasad Narayan, Gupta Amit, Srivastava Janmejai Kumar
Abstract excerpt
BACKGROUND: Toll-like receptors (TLRs), expressed on cells of the innate immune system, are the first line of host defense. Recognition of bacterial pathogens by the peritoneum is mediated in part by TLR. In this study, we investigated the role of TLR4 (Asp299Gly and Thr399Ile) and TLR2 (Arg677Trp and Arg753Gln) gene polymorphisms in end-stage renal disease (ESRD) patients on peritoneal dialysis (PD). METHOD: A...
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