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Article

An intronic PICALM polymorphism, rs588076, is associated with allelic expression of a PICALM isoform.

Molecular neurodegeneration - 29 Aug 2014

Parikh Ishita, Medway Christopher, Younkin Steven, Fardo David W, Estus Steven

Abstract excerpt

BACKGROUND: Although genome wide studies have associated single nucleotide polymorphisms (SNP)s near PICALM with Alzheimer's disease (AD), the mechanism underlying this association is unclear. PICALM is involved in clathrin-mediated endocytosis and modulates Aß clearance in vitro. Comparing allelic expression provides the means to detect cis-acting regulatory polymorphisms. Thus, we evaluated whether PICALM...

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Source

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Identifiers

PMID: 25169757
DOI: 10.1186/1750-1326-9-32
PMCID: PMC4150683

Genes

PICALM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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