PICALM Genetic Variant Alters mRNA Expression Without Affecting Protein Levels or Tau Spreading in Alzheimer's Disease.

doi:10.3390/cells15030235

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PICALM Genetic Variant Alters mRNA Expression Without Affecting Protein Levels or Tau Spreading in Alzheimer's Disease.

Cells - 26 Jan 2026

Ando Kunie, Lopez-Gutierrez Lidia, Mansour Salwa, Yilmaz Zehra, Dauphinot Luce, Verheijen Jan, Fontaine Gaëlle, Quintanilla-Sánchez Carolina, Aydin Emmanuel, Doeraene Emilie, Nagaraj Siranjeevi, Kosa Andreea-Claudia, Watanabe Toshio, Sleegers Kristel, Potier Marie-Claude, Brion Jean-Pierre, Leroy Karelle

Abstract excerpt

Phosphatidylinositol-binding clathrin assembly protein (PICALM) is a clathrin adaptor essential for clathrin-mediated endocytosis. Genome-wide association studies (GWAS) have consistently identified PICALM as one of the most significant genetic susceptibility loci for late-onset sporadic Alzheimer's disease (AD). However, the functional impact of the most validated AD-associated variant, rs3851179, remains...

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PMID: 41677602
DOI: 10.3390/cells15030235
PMCID: PMC12897012

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PICALM

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