Article
Next-generation DNA sequencing-based assay for measuring allelic expression imbalance (AEI) of candidate neuropsychiatric disorder genes in human brain.
BMC genomics - 20 Oct 2011
Xu Xiang, Wang Hao, Zhu Min, Sun Yue, Tao Yu, He Qin, Wang Jian, Chen Li, Saffen David
Abstract excerpt
BACKGROUND: Common genetic variants that regulate gene expression are widely suspected to contribute to the etiology and phenotypic variability of complex diseases. Although high-throughput, microarray-based assays have been developed to measure differences in mRNA expression among independent samples, these assays often lack the sensitivity to detect rare mRNAs and the reproducibility to quantify small changes...
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