Article
Posterior cingulate γ-aminobutyric acid and glutamate/glutamine are reduced in amnestic mild cognitive impairment and are unrelated to amyloid deposition and apolipoprotein E genotype.
Neurobiology of aging - 1 Jan 2015
Riese Florian, Gietl Anton, Zölch Niklaus, Henning Anke, O'Gorman Ruth, Kälin Andrea M, Leh Sandra E, Buck Alfred, Warnock Geoffrey, Edden Richard A E, Luechinger Roger, Hock Christoph, Kollias Spyros, Michels Lars
Abstract excerpt
The biomarker potential of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) for the in vivo characterization of preclinical stages in Alzheimer's disease has not yet been explored. We measured GABA, glutamate + glutamine (Glx), and N-acetyl-aspartate (NAA) levels by single-voxel MEGA-PRESS magnetic resonance spectroscopy in the posterior cingulate cortex of 21 elderly subjects and 15 patients with...
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