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Article

Relationship between genetic variation in the glutaminase gene GLS1 and brain glutamine/glutamate ratio measured in vivo.

Biological psychiatry - 15 Jul 2011

Öngür Dost, Haddad Stephen, Prescot Andrew P, Jensen J Eric, Siburian Richie, Cohen Bruce M, Renshaw Perry F, Smoller Jordan W

Abstract excerpt

BACKGROUND: Abnormalities in glutamatergic neurotransmission are implicated in several psychiatric disorders, but in vivo neurochemical studies of the glutamate (Glu) system have been hampered by a lack of adequate probes. By contrast, glutamine (Gln) and Glu can be quantified separately in proton magnetic resonance spectroscopy studies in vivo. Accumulating evidence suggests that the Gln/Glu ratio is a putative...

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Identifiers

PMID: 21457947
DOI: 10.1016/j.biopsych.2011.01.033
PMCID: PMC3125415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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