Article
Decreased glutamate + glutamine in Alzheimer’s disease detected in vivo with <sup>1</sup> H-MRS at 0.5 T
27 Mar 2001
Abstract excerpt
OBJECTIVE: To determine whether glutamate + glutamine (GLX) levels in the brain as measured in vivo with proton MRS at 0.5 tesla (T) distinguish between probable Alzheimer's disease and normal aging. BACKGROUND: Glutamatergic markers had been measured previously in postmortem brain tissue. Conventional proton MRS at 1.5 T cannot reliably detect the GLX resonance in vivo. The authors developed a technique at 0.5 T...