Article
Frequent co-inactivation of the SWI/SNF subunits SMARCB1, SMARCA2 and PBRM1 in malignant rhabdoid tumours.
Histopathology - 1 Jul 2015
Rao Qiu, Xia Qiu-yuan, Wang Zi-yu, Li Li, Shen Qin, Shi Shan-shan, Wang Xuan, Liu Biao, Wang Yan-fen, Shi Qun-li, Ma Heng-hui, Lu Zhen-feng, He Yan, Zhang Ru-song, Yu Bo, Zhou Xiao-jun
Abstract excerpt
AIMS: Malignant rhabdoid tumours (MRTs) are highly aggressive malignancies of early infancy characterized by inactivation of SMARCB1, a core member of the SWI/SNF chromatin-remodelling complex. The aim of this study was to explore the status of multiple key subunits of the SWI/SNF complex in MRTs. METHODS AND RESULTS: We screened the key subunits of the SWI/SNF complex, including SMARCB1, SMARCA2, PBRM1, SMARCA4,...
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