Article
Expression of the HSF4 DNA binding domain-EGFP hybrid gene recreates early childhood lamellar cataract in transgenic mice.
Investigative ophthalmology & visual science - 28 Aug 2014
Gangalum Rajendra K, Jing Zhe, Bhat Ankur M, Lee Josh, Nagaoka Yoshiko, Deng Sophie X, Jiang Meisheng, Bhat Suraj P
Abstract excerpt
PURPOSE: The clinical management of cataracts in infancy involves surgical removal of the lens to ensure transmission of light to the retina, which is essential for normal neural development of the infant. This surgery, however, entails a lifelong follow-up and impaired vision. To our knowledge, no animal models recapitulate human lamellar opacities, the most prevalent form of early childhood cataracts. We...
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