Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation in HSF4 is associated with hereditary cataract in the Australian Shepherd.

Veterinary ophthalmology - 1 Jan 2000

Mellersh Cathryn S, McLaughlin Bryan, Ahonen Saija, Pettitt Louise, Lohi Hannes, Barnett Keith C

Abstract excerpt

Cataracts are a leading cause of blindness in dogs with approximately 100 breeds affected by primary hereditary forms. Despite the large number of breeds affected with hereditary cataracts (HC) little is known about the genetics of the condition, and to date only a single gene, HSF4, has been implicated in the development of the disease in dogs. We previously identified a recessively inherited 1-bp insertion in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dog Diseases
Share to Dogs
Share to Alleles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cataract

Share to Gene Deletion

Share to Genetic Predisposition to Disease

Share to Genotype

Share to Transcription Factors

Source

Identifiers

PMID: 19883468
DOI: 10.1111/j.1463-5224.2009.00735.x

Genes

HSF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation in HSF4 is associated with hereditary cataract in the Australian Shepherd.PMID 19883468Read ↗

Identification of mutations in HSF4 in dogs of three different breeds with hereditary cataracts.Semantic proximity Read ↗

Mutation in HSF4 associated with early but not late-onset hereditary cataract in the Boston Terrier.Semantic proximity Read ↗

A novel locus on canine chromosome 13 is associated with cataract in the Australian Shepherd breed of domestic dog.Semantic proximity Read ↗

Evaluation of canine heat shock transcription factor 4 (HSF4) as a candidate gene for primary cataracts in the Dachshund and the Entlebucher Mountain dog.Semantic proximity Read ↗

Inheritance of cataracts and primary lens luxation in Jack Russell Terriers.Semantic proximity Read ↗

Evaluation of three canine gamma-crystallins (CRYGB, CRYGC, and CRYGS) as candidates for hereditary cataracts in the dachshund.Semantic proximity Read ↗

Mapping the mutation causing lens luxation in several terrier breeds.Semantic proximity Read ↗

Dogs and humans share a common susceptibility gene SRBD1 for glaucoma risk.Semantic proximity Read ↗

Heritability estimates of distichiasis in Staffordshire bull terriers using pedigrees and genome-wide SNP data.Semantic proximity Read ↗

Multiocular defect in the Old English Sheepdog: A canine form of Stickler syndrome type II associated with a missense variant in the collagen-type gene COL11A1.Semantic proximity Read ↗

Allele and genotype frequencies for primary hereditary cataract, multifocal retinopathy 1, and degenerative myelopathy in Pyrenean Mountain dog from Italy.Semantic proximity Read ↗

A novel HSF4 gene mutation causes autosomal-dominant cataracts in a Chinese family.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.