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Article

Insertion of a Pax6 Consensus Binding Site into the αA-Crystallin Promoter Acts as a Lens Epithelial Cell Enhancer in Transgenic Mice

24 May 2004

Abstract excerpt

PURPOSE: Although the murine alphaA-crystallin promoter is the most commonly used promoter for achieving transgene expression in the developing lens, this promoter directs transgene expression efficiently only in lens fiber cells. The purpose of the present study was to generate promoters capable of directing transgene expression to the entire lens but not to the corneal epithelium. METHODS: Transgenic mice were...

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PMID: 15161860
DOI: 10.1167/iovs.03-0856

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