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Article

Overexpression of human γC-crystallin 5 bp duplication disrupts lens morphology in transgenic mice.

Investigative ophthalmology & visual science - 23 Jul 2011

Ma Zhiwei, Yao Wenliang, Theendakara Veena, Chan Chi-Chao, Wawrousek Eric, Hejtmancik J Fielding

Abstract excerpt

PURPOSE: To delineate the molecular mechanisms underlying autosomal dominant congenital cataracts caused by a 5 bp duplication in human CRYGC. METHODS: c.119_123dup (CRYGC5bpd) and wild-type human γC-crystallin (CRYGC) were expressed in transgenic mouse lenses by the chicken βB1-crystallin promoter. Lenses were characterized histologically, by real-time PCR, SDS-PAGE, and Western blot. pET and Tet-on expression...

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Source

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Identifiers

PMID: 21436266
DOI: 10.1167/iovs.11-7168
PMCID: PMC3176079

Genes

CRYGC
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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