Article
Genetic dissection of susceptibility genes for diabetes and related phenotypes on mouse chromosome 14 by means of congenic strains.
BMC genetics - 29 Aug 2014
Babaya Naru, Ueda Hironori, Noso Shinsuke, Hiromine Yoshihisa, Itoi-Babaya Michiko, Kobayashi Misato, Fujisawa Tomomi, Ikegami Hiroshi
Abstract excerpt
BACKGROUND: A susceptibility locus, Nidd2n, for type 2 diabetes has been mapped to mouse chromosome 14 (Chr 14) and confirmed using the consomic strain (C3H-Chr 14NSY) of the Nagoya-Shibata-Yasuda (NSY) mouse, an animal model of spontaneous type 2 diabetes. The aim of this study was to localize and characterize Nidd2n. RESULTS: We constructed two novel congenic strains homozygous for different segments of NSY-Chr...
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