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Article

Identification of a critical interval for type 2 diabetes QTL on chromosome 4 in DDD-Ay mice.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Mar 2025

Suto Jun-Ichi, Kojima Misaki

Abstract excerpt

Type 2 diabetes mellitus (T2D) in male KK-Ay and B6-Ay mice is typically associated with hyperinsulinemia, whereas male DDD-Ay mice exhibit a marked decrease in circulating insulin levels due to the loss of pancreatic islet β-cells. T2D in male DDD-Ay mice is linked to Nidd/DDD, a significant quantitative trait locus (QTL) mapped with a 95% confidence interval (CI) between 112.44 and 151.47 Mbp on chromosome 4....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 39833475
DOI: 10.1007/s00335-025-10106-2

Genes

F2

Variants

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