Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Quantitative trait locus dissection in congenic strains of the Goto-Kakizaki rat identifies a region conserved with diabetes loci in human chromosome 1q.

Physiological genomics - 16 Sept 2004

Wallace Karin J, Wallis Robert H, Collins Stephan C, Argoud Karène, Kaisaki Pamela J, Ktorza Alain, Woon Peng Y, Bihoreau Marie-Thérèse, Gauguier Dominique

Abstract excerpt

Genetic studies in human populations and rodent models have identified regions of human chromosome 1q21-25 and rat chromosome 2 showing evidence of significant and replicated linkage to diabetes-related phenotypes. To investigate the relationship between the human and rat diabetes loci, we fine mapped the rat locus Nidd/gk2 linked to hyperinsulinemia in an F2 cross derived from the diabetic (type 2) Goto-Kakizaki...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Congenic
Share to Chromosomes, Human, Pair 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucose Intolerance

Share to Hyperinsulinism

Share to Insulin Secretion

Share to Lipids

Share to Rats, Inbred BN

Share to Rats, Inbred Strains

Source

Identifiers

PMID: 15266047
DOI: 10.1152/physiolgenomics.00114.2004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Quantitative trait locus dissection in congenic strains of the Goto-Kakizaki rat identifies a region conserved with diabetes loci in human chromosome 1q.PMID 15266047Read ↗

High-resolution quantitative trait locus analysis reveals multiple diabetes susceptibility loci mapped to intervals<800 kb in the species-conserved Niddm1i of the GK rat.Semantic proximity Read ↗

Pathophysiological and genetic characterization of the major diabetes locus in GK rats.Semantic proximity Read ↗

Enhanced insulin secretion and cholesterol metabolism in congenic strains of the spontaneously diabetic (Type 2) Goto Kakizaki rat are controlled by independent genetic loci in rat chromosome 8.Semantic proximity Read ↗

Comparative Genome of GK and Wistar Rats Reveals Genetic Basis of Type 2 Diabetes.Semantic proximity Read ↗

Genomic regulation of type 2 diabetes endophenotypes: Contribution from genetic studies in the Goto-Kakizaki rat.Semantic proximity Read ↗

Single diabetic QTL derived from OLETF rat is a sufficient agent for severe diabetic phenotype in combination with leptin-signaling deficiency.Semantic proximity Read ↗

Identification of a novel gene for diabetic traits in rats, mice, and humans.Semantic proximity Read ↗

Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats.Semantic proximity Read ↗

Conserved properties of genetic architecture of renal and fat transcriptomes in rat models of insulin resistanceSemantic proximity Read ↗

A novel susceptibility locus on rat chromosome 8 affects spontaneous but not experimentally induced type 1 diabetes.Semantic proximity Read ↗

Mouse models of type 1 and type 2 diabetes derived from the same closed colony: genetic susceptibility shared between two types of diabetes.Semantic proximity Read ↗

Genetic dissection of susceptibility genes for diabetes and related phenotypes on mouse chromosome 14 by means of congenic strains.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.