Article
Direct evidence for susceptibility genes for type 2 diabetes on mouse chromosomes 11 and 14.
Diabetologia - 1 Jul 2010
Babaya N, Fujisawa T, Nojima K, Itoi-Babaya M, Yamaji K, Yamada K, Kobayashi M, Ueda H, Hiromine Y, Noso S, Ikegami H
Abstract excerpt
AIMS/HYPOTHESIS: Diabetogenic loci for type 2 diabetes have been mapped to mouse chromosome (Chr) 11 and 14 in the Nagoya-Shibata-Yasuda (NSY) mouse, an animal model of type 2 diabetes. We aimed to obtain direct evidence of these genes on each chromosome and to clarify their function and interaction in conferring susceptibility to type 2 diabetes. METHODS: We established three consomic strains homozygous for...
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