Article
KIR ligand C2 is associated with increased susceptibility to childhood ALL and confers an elevated risk for late relapse.
Blood - 2 Oct 2014
Babor Florian, Manser Angela R, Fischer Johannes C, Scherenschlich Nadine, Enczmann Jürgen, Chazara Olympe, Moffett Ashley, Borkhardt Arndt, Meisel Roland, Uhrberg Markus
Abstract excerpt
A role for HLA class I polymorphism in childhood acute lymphoblastic leukemia (ALL) has been suggested for many years, but unambiguous associations have not been found. Here, we show that the HLA-C-encoded supertypic epitope C2, which constitutes a high-affinity ligand for the inhibitory natural killer (NK) cell receptor KIR2DL1, is significantly increased in ALL patients (n = 320; P = .005). Stratification for...
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