Article
Homozygosity for human leucocyte antigen-C ligands of KIR2DL1 is associated with increased risk of relapse after human leucocyte antigen-C-matched unrelated donor haematopoietic stem cell transplantation.
British journal of haematology - 1 Nov 2005
Giebel Sebastian, Locatelli Franco, Wojnar Jerzy, Velardi Andrea, Mina Tommaso, Giorgiani Giovanna, Krawczyk-Kulis Malgorzata, Markiewicz Miroslaw, Wylezol Iwona, Holowiecki Jerzy
Abstract excerpt
Human leucocyte antigen (HLA)-C molecules regulate the function of natural killer cells and may be subdivided into two groups, C(1) and C(2), based on their specificity for inhibitory killer immunoglobulin-like receptors. We analysed the impact of the HLA-C genotype on outcome of HLA-C-matched unrelated donor haematopoietic stem cell transplantation (URD-HSCT) recipients. HLA-C(2) homozygous patients (n = 18) had...
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