Article
Identity-by-descent mapping in a Scandinavian multiple sclerosis cohort.
European journal of human genetics : EJHG - 1 May 2015
Westerlind Helga, Imrell Kerstin, Ramanujam Ryan, Myhr Kjell-Morten, Celius Elisabeth Gulowsen, Harbo Hanne F, Oturai Annette Bang, Hamsten Anders, Alfredsson Lars, Olsson Tomas, Kockum Ingrid, Koski Timo, Hillert Jan
Abstract excerpt
In an attempt to map chromosomal regions carrying rare gene variants contributing to the risk of multiple sclerosis (MS), we identified segments shared identical-by-descent (IBD) using the software BEAGLE 4.0's refined IBD analysis. IBD mapping aims at identifying segments inherited from a common ancestor and shared more frequently in case-case pairs. A total of 2106 MS patients of Nordic origin and 624 matched...
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