Article
Investigation of seven proposed regions of linkage in multiple sclerosis: an American and French collaborative study.
Neurogenetics - 1 Feb 2004
Pericak-Vance Margaret A, Rimmler Jackie B, Haines Jonathan L, Garcia Melissa E, Oksenberg Jorge R, Barcellos Lisa F, Lincoln Robin, Hauser Stephen L, Cournu-Rebeix Isabelle, Azoulay-Cayla Ariele, Lyon-Caen Olivier, Fontaine Bertrand, Duhamel Emmanuelle, Coppin Helene, Brassat David, Roth Marie-Paule, Clanet Michel, Alizadeh Mehdi, Yaouanq Jacqueline, Quelvennec Erwann, Semana Gilbert, Edan Gilles, Babron Marie-Claude, Genin Emmanuelle, Clerget-Darpoux Francoise
Abstract excerpt
Multiple sclerosis (MS) is a demyelinating autoimmune disease with a strong yet complex genetic component. To date only the HLA-DR locus, and specifically the HLA-DR15 allele, has been identified and confirmed as influencing the risk of developing MS. Genomic screens on several datasets have been performed and have identified several chromosomal regions with interesting results, but none have yet been confirmed....
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