Article
A whole genome association study in Icelandic multiple sclerosis patients with 4804 markers.
Journal of neuroimmunology - 1 Oct 2003
Jonasdottir Aslaug, Thorlacius Theodora, Fossdal Ragnheidur, Jonasdottir Adalbjorg, Benediktsson Kjartan, Benedikz John, Jonsson Hjortur H, Sainz Jesus, Einarsdottir Helga, Sigurdardottir Sonja, Kristjansdottir Gudlaug, Sawcer Stephen, Compston Alastair, Stefansson Kari, Gulcher Jeffrey
Abstract excerpt
Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system (CNS) with a complex genetic background. Here we use a genome-wide association strategy with 4804 microsatellite markers successfully typed in separately pooled DNA from 200 patients and 200 controls. A total of 91 markers showed evidence of association. When compared to our in-house physical map of the genome, six 2-Mb regions...
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