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Article

Leveraging Identity-by-Descent for Disease Gene Discovery.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2026

Henden Lyndal

Abstract excerpt

Genomic regions inherited from a common ancestor are said to be identical-by-descent (IBD). These IBD regions, or segments, can be leveraged to aid in the discovery of disease-associated genetic variation in the absence of large cohorts or pedigrees. In this approach, genetic relatedness is established between affected individuals through the detection of IBD segments. Shared segments that segregate with the...

Read the complete abstract on PubMed

Topics

Humans
Polymorphism, Single Nucleotide
Genetic Predisposition to Disease
Genomics
Pedigree
Chromosome Mapping
Computational Biology

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Genome-Wide Association Study

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PMID: 42681306
DOI: 10.1007/978-1-0716-5440-8_15

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