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Article

Identity-by-descent mapping to detect rare variants conferring susceptibility to multiple sclerosis.

PloS one - 1 Jan 2013

Lin Rui, Charlesworth Jac, Stankovich Jim, Perreau Victoria M, Brown Matthew A, Taylor Bruce V

Abstract excerpt

Genome-wide association studies (GWAS) have identified around 60 common variants associated with multiple sclerosis (MS), but these loci only explain a fraction of the heritability of MS. Some missing heritability may be caused by rare variants that have been suggested to play an important role in the aetiology of complex diseases such as MS. However current genetic and statistical methods for detecting rare...

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Identifiers

PMID: 23472070
DOI: 10.1371/journal.pone.0056379
PMCID: PMC3589405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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