P53 and induction of apoptosis as a target for anticancer therapy.

Article

P53 and induction of apoptosis as a target for anticancer therapy.

Leukemia - 1 Jul 1996

Neubauer A, Thiede C, Huhn D, Wittig B

Abstract excerpt

p53 is the most frequently mutated gone in human cancer cells. Its wild-type gone encodes for a protein with pivotal functions: (i) interaction with key players in the cell cycle leading to cell cycle arrest; (ii) induction of programmed call death, or apoptosis. P53 may be seen as another member...

Topics

Animals
Apoptosis
Genes, p53
Genetic Therapy
Humans
Mutation
Neoplasms
Prognosis

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