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Article

Replicational stress selects for p53 mutation.

Cell cycle (Georgetown, Tex.) - 1 Sept 2007

Marusyk Andriy, DeGregori James

Abstract excerpt

p53 is a critical mediator of cellular responses to a variety of stresses. Given the frequency of p53 mutations in human malignancies and that disruption of p53 has been implicated in chemoresistance, understanding the factors that select for p53 disruption is important both for understanding tumor evolution and for designing cancer therapies. While it is widely believed that genotoxic stress selects for p53...

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Identifiers

PMID: 17786047
DOI: 10.4161/cc.6.17.4732
PMCID: PMC2394679

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RAD51

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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