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Article

Energy metabolism during anchorage-independence. Induction by osteopontin-c.

PloS one - 1 Jan 2014

Shi Zhanquan, Wang Bo, Chihanga Tafadzwa, Kennedy Michael A, Weber Georg F

Abstract excerpt

The detachment of epithelial cells, but not cancer cells, causes anoikis due to reduced energy production. Invasive tumor cells generate three splice variants of the metastasis gene osteopontin, the shortest of which (osteopontin-c) supports anchorage-independence. Osteopontin-c signaling upregulates three interdependent pathways of the energy metabolism. Glutathione, glutamine and glutamate support the hexose...

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Identifiers

PMID: 25157961
DOI: 10.1371/journal.pone.0105675
PMCID: PMC4144875

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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