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Metabolic Reprogramming of Ovarian Cancer Spheroids during Adhesion

9 Mar 2022

Abstract excerpt

Ovarian cancer remains a deadly disease and its recurrence disease is due in part to the presence of disseminating ovarian cancer aggregates not removed by debulking surgery. During dissemination in a dynamic ascitic environment, the spheroid cells' metabolism is characterized by low respiration and fragmented mitochondria, a metabolic phenotype that may not support secondary outgrowth after adhesion. Here, we...

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PMID: 35326551
DOI: 10.3390/cancers14061399

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