Article
Spheroid cancer stem cells display reprogrammed metabolism and obtain energy by actively running the tricarboxylic acid (TCA) cycle.
Oncotarget - 31 May 2016
Sato Masakazu, Kawana Kei, Adachi Katsuyuki, Fujimoto Asaha, Yoshida Mitsuyo, Nakamura Hiroe, Nishida Haruka, Inoue Tomoko, Taguchi Ayumi, Takahashi Juri, Eguchi Satoko, Yamashita Aki, Tomio Kensuke, Wada-Hiraike Osamu, Oda Katsutoshi, Nagamatsu Takeshi, Osuga Yutaka, Fujii Tomoyuki
Abstract excerpt
The Warburg effect is a metabolic hallmark of cancer cells; cancer cells, unlike normal cells, exclusively activate glycolysis, even in the presence of enough oxygen. On the other hand, intratumoral heterogeneity is currently of interest in cancer research, including that involving cancer stem cells (CSCs). In the present study, we attempted to gain an understanding of metabolism in CSCs that is distinct from...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.