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Article

Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways.

The Journal of clinical investigation - 1 Jan 2014

Onodera Yasuhito, Nam Jin-Min, Bissell Mina J

Abstract excerpt

There is a considerable resurgence of interest in the role of aerobic glycolysis in cancer; however, increased glycolysis is frequently viewed as a consequence of oncogenic events that drive malignant cell growth and survival. Here we provide evidence that increased glycolytic activation itself can be an oncogenic event in a physiologically relevant 3D culture model. Overexpression of glucose transporter type 3...

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Identifiers

PMID: 24316969
DOI: 10.1172/JCI63146
PMCID: PMC3871217

Genes

EGFR

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