Characterization of long‐term <i>in vitro</i> culture‐related alterations of human tonsil‐derived mesenchymal stem cells: role for <scp>CCN</scp>1 in replicative senescence‐associated increase in osteogenic differentiation

Abstract excerpt

Although mesenchymal stem cells (MSC) isolated from bone marrow and adipose tissues are known to be subjected to in vitro culture-related alterations in their stem cell properties, such data have not been reported in human tonsil-derived MSC (T-MSC). Here, we investigated the culture-related changes of phenotypes, the senescence, and the differentiation potential of T-MSC. T-MSC were serially passaged by a...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Connective Tissue Growth Factor Research
• Share to Mesenchymal stem cell research