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Article

Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process

20 May 2008

Abstract excerpt

Mesenchymal stem cells (MSC) comprise a promising tool for cellular therapy. These cells are usually culture expanded prior to their application. However, a precise molecular definition of MSC and the sequel of long-term in vitro culture are yet unknown. In this study, we have addressed the impact of replicative senescence on human MSC preparations. Within 43 to 77 days of cultivation (7 to 12 passages), MSC...

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PMID: 18493317
DOI: 10.1371/journal.pone.0002213

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