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Article

Changes in phenotype and differentiation potential of human mesenchymal stem cells aging in vitro.

Stem cell research & therapy - 11 May 2018

Yang Yueh-Hsun Kevin, Ogando Courtney R, Wang See Carmine, Chang Tsui-Yun, Barabino Gilda A

Abstract excerpt

BACKGROUND: Adult mesenchymal stem cells (MSCs) hold great promise for regenerative medicine because of their self-renewal, multipotency, and trophic and immunosuppressive effects. Due to the rareness and high heterogeneity of freshly isolated MSCs, extensive in-vitro passage is required to expand their populations prior to clinical use; however, senescence usually accompanies and can potentially affect MSC...

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Identifiers

PMID: 29751774
DOI: 10.1186/s13287-018-0876-3
PMCID: PMC5948736

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MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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