Phenotypic alterations and PI3K-AKT pathway regulation in senescence of human tonsil mesenchymal stem cells.

doi:10.1186/s13287-026-04986-7

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Phenotypic alterations and PI3K-AKT pathway regulation in senescence of human tonsil mesenchymal stem cells.

Stem cell research & therapy - 27 Mar 2026

Qiu Xiaoyu, Lin Zehua, Sun Yuechen, Zhao Anbang, Chen Xiong

Abstract excerpt

BACKGROUND: Tonsil mesenchymal stem cells (TMSCs) are a promising regenerative medicine source but require continuous subculturing for expansion. Long-term expansion in vitro induces cellular senescence, impairing their function. This study aimed to elucidate senescence-related phenotypic alterations and regulatory mechanisms in human tonsil-derived mesenchymal stem cells. METHODS: Human-derived TMSCs were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to Cells, Cultured
Share to Cellular Senescence
Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mesenchymal Stem Cells

Share to Palatine Tonsil

Share to Phosphatidylinositol 3-Kinases

Share to Proto-Oncogene Proteins c-akt

Source

Open in PubMed Open full text

Identifiers

PMID: 41896931
DOI: 10.1186/s13287-026-04986-7
PMCID: PMC13147630

Genes

Provenance

PubMed metadata and Literature Corpus relationships.