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Article

Phenotypic changes associated with continuous long term in vitro expansion of bone marrow-derived mesenchymal stem cells.

Biochimie - 1 Jul 2025

Maldonado Vitali V, Jensen Hanna, Barnes C Lowry, Samsonraj Rebekah M

Abstract excerpt

In vitro expansion of mesenchymal stem cells is necessary to obtain a higher cell number for clinical applications. However, long-term expansion can produce significant phenotypic changes on these cells, decreasing their therapeutic utility. Therefore, understanding the phenotypic changes that long-term expansion triggers in mesenchymal stem cells will allow for better and more consistent cell therapy results....

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Identifiers

PMID: 40209891
DOI: 10.1016/j.biochi.2025.04.002
PMCID: PMC13283746

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CD4

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