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Phenotypic Alterations and PI3K-AKT Pathway Regulation in Senescence of Human Tonsil Mesenchymal Stem Cells

2025-10-27

Abstract excerpt

<title>Abstract</title> <p>Background Tonsil mesenchymal stem cells (TMSCs) are a promising regenerative medicine source but require continuous subculturing for expansion. Long-term expansion in vitro induces cellular senescence, impairing their function. This study aimed to elucidate senescence-related phenotypic alterations and regulatory mechanisms in human tonsil-derived mesenchymal stem cells. Methods Human-...

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Literature Corpus work
a0cf5258-dd2d-5118-a507-32a88ffa1cd3
DOI
10.21203/rs.3.rs-7580821/v1
Open publication

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Phenotypic Alterations and PI3K-AKT Pathway Regulation in Senescence of Human Tonsil Mesenchymal Stem CellsDOI 10.21203/rs.3.rs-7580821/v1
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