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Article

Long-term <i>In vitro</i> Expansion Alters the Biology of Adult Mesenchymal Stem Cells

1 Jun 2008

Abstract excerpt

Mesenchymal stem cells (MSC) derived from bone marrow stem cells (BMSC) and adipose tissue stem cells (ASC) of humans and rhesus macaques were evaluated for their cell cycle properties during protracted culture in vitro. Human ASCs (hASC) and rhesus BMSCs (rBMSC) underwent significantly more total population doublings than human BMSCs (hBMSC) and rhesus ASCs (rASC). The cell cycle profile of all MSCs was altered...

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PMID: 18519682
DOI: 10.1158/0008-5472.can-07-5272

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