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Article

Distinct roles of CSF-1 isoforms in lupus nephritis.

Journal of the American Society of Nephrology : JASN - 1 Oct 2011

Menke Julia, Iwata Yasunori, Rabacal Whitney A, Basu Ranu, Stanley E Richard, Kelley Vicki R

Abstract excerpt

Colony-stimulating factor-1 (CSF-1), the principal growth factor for macrophages, is increased in the kidney, serum, and urine of patients with lupus nephritis, and eliminating CSF-1 suppresses lupus in MRL-Fas(lpr) mice. CSF-1 has three biologically active isoforms: a membrane-spanning cell surface glycoprotein (csCSF-1), a secreted proteoglycan (spCSF-1), and a secreted glycoprotein (sgCSF-1); the role of each...

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Identifiers

PMID: 21885670
DOI: 10.1681/ASN.2011010038
PMCID: PMC3187183

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