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Article

Decrease of 5-hydroxymethylcytosine in rat liver with subchronic exposure to genotoxic carcinogens riddelliine and aristolochic acid.

Molecular carcinogenesis - 1 Nov 2015

Lian Christine Guo, Xu Shuyun, Guo Weimin, Yan Jian, Frank Maximilian Y M, Liu Robert, Liu Cynthia, Chen Ying, Murphy George F, Chen Tao

Abstract excerpt

The level of 5-hydroxymethylcytosine (5-hmC) converted by ten-eleven translocation (TET) family is decreased in cancers. However, whether 5-hmC level is perturbed in early stages of carcinogenesis caused by genotoxic carcinogens is not defined. 5-hmC levels and TET2 expression were measured in liver of rats treated with genotoxic carcinogens, riddelliine, or aristolochic acid. Levels of 5-hmC and TET2 expression...

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Source

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Identifiers

PMID: 25154389
DOI: 10.1002/mc.22201
PMCID: PMC5832966

Genes

TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Decrease of 5-hydroxymethylcytosine in rat liver with subchronic exposure to genotoxic carcinogens riddelliine and aristolochic acid.PMID 25154389Read ↗

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