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Article

Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome

3 Oct 2012

Abstract excerpt

BACKGROUND: Induction and promotion of liver cancer by exposure to non-genotoxic carcinogens coincides with epigenetic perturbations, including specific changes in DNA methylation. Here we investigate the genome-wide dynamics of 5-hydroxymethylcytosine (5hmC) as a likely intermediate of 5-methylcytosine (5mC) demethylation in a DNA methylation reprogramming pathway. We use a rodent model of non-genotoxic...

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PMID: 23034186
DOI: 10.1186/gb-2012-13-10-r93

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