Reaction coupling between wild-type and disease-associated mutant EZH2.

doi:10.1021/cb500548b

Article

Reaction coupling between wild-type and disease-associated mutant EZH2.

ACS chemical biology - 21 Nov 2014

Swalm Brooke M, Knutson Sarah K, Warholic Natalie M, Jin Lei, Kuntz Kevin W, Keilhack Heike, Smith Jesse J, Pollock Roy M, Moyer Mikel P, Scott Margaret Porter, Copeland Robert A, Wigle Tim J

Abstract excerpt

EZH2 and EZH1 are protein methyltransferases (PMTs) responsible for histone H3, lysine 27 (H3K27) methylation. Trimethylation of H3K27 (H3K27me3) is a hallmark of many cancers, including non-Hodgkin lymphoma (NHL). Heterozygous EZH2 point mutations at Tyr641, Ala677, and Ala687 have been observed...

Topics

Enhancer of Zeste Homolog 2 Protein
Humans
Mutation
Neoplasms
Polycomb Repressive Complex 2

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