Polymorphism of the flap endonuclease 1 gene in keratoconus and Fuchs endothelial corneal dystrophy.

doi:10.3390/ijms150814786

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Article

Polymorphism of the flap endonuclease 1 gene in keratoconus and Fuchs endothelial corneal dystrophy.

International journal of molecular sciences - 22 Aug 2014

Wojcik Katarzyna A, Synowiec Ewelina, Polakowski Piotr, Głowacki Sylwester, Izdebska Justyna, Lloyd Sophie, Galea Dieter, Blasiak Janusz, Szaflik Jerzy, Szaflik Jacek P

Abstract excerpt

Oxidative stress is implicated in the pathogenesis of many diseases, including serious ocular diseases, keratoconus (KC) and Fuchs endothelial corneal dystrophy (FECD). Flap endonuclease 1 (FEN1) plays an important role in the repair of oxidative DNA damage in the base excision repair pathway. We determined the association between two single nucleotide polymorphisms (SNPs), c.-441G>A (rs174538) and g.61564299G>T...

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Identifiers

PMID: 25153632
DOI: 10.3390/ijms150814786
PMCID: PMC4159882

Genes

FEN1

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