Article
Polymorphism of the transferrin gene in eye diseases: keratoconus and Fuchs endothelial corneal dystrophy.
BioMed research international - 1 Jan 2013
Wójcik Katarzyna A, Synowiec Ewelina, Jiménez-García Manuel P, Kaminska Anna, Polakowski Piotr, Blasiak Janusz, Szaflik Jerzy, Szaflik Jacek P
Abstract excerpt
Oxidative stress may play a role in the pathogenesis of keratoconus (KC) and Fuchs endothelial corneal dystrophy (FECD). Iron may promote the stress by the Fenton reaction, so its homeostasis should be strictly controlled. Transferrin is essential for iron homeostasis because it transports iron from plasma into cells. The malfunction of transferrin, which may be caused by variation in its gene (TF) variation, may...
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