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Article

Dysregulation of DNA repair genes in Fuchs endothelial corneal dystrophy.

Experimental eye research - 1 Jun 2023

Ashraf Shazia, Deshpande Neha, Vasanth Shivakumar, Melangath Geetha, Wong Raymond J, Zhao Yan, Price Marianne O, Price Francis W, Jurkunas Ula V

Abstract excerpt

Fuchs Endothelial Corneal Dystrophy (FECD), a late-onset oxidative stress disorder, is the most common cause of corneal endothelial degeneration and is genetically associated with CTG repeat expansion in Transcription Factor 4 (TCF4). We previously reported accumulation of nuclear (nDNA) and mitochondrial (mtDNA) damage in FECD. Specifically, mtDNA damage was a prominent finding in development of disease in the...

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Share to DNA Glycosylases
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Endothelium, Corneal

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Share to Genetic Predisposition to Disease

Source

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Identifiers

PMID: 37169279
DOI: 10.1016/j.exer.2023.109499
PMCID: PMC10246500

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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