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The Contribution of Flap Endonuclease 1 Genotypes to Oral Cancer Risk.

Anticancer research - 1 Sept 2022

Pan Shih-Han, Chien Wei-Ching, He Jie-Long, Shih Liang-Chun, Hsu Che-Lun, Hsia Te-Chun, Wang Yun-Chi, Tsao Hao-Yuan, Tsai Chia-Wen, Bau DA-Tian, Chang Wen-Shin

Abstract excerpt

BACKGROUND/AIM: Flap endonuclease 1 (FEN1) is a critical protein in DNA repair, genomic stability, and carcinogenesis. Functional polymorphisms in FEN1 promoter -69G>A (rs174538) and 3'UTR 4150G>T (rs4246215), have been associated with the susceptibility to several cancers, including lung, breast, esophageal, gastric, liver, colorectal, and gallbladder cancer, as well as glioma, endometriosis, and leukemia....

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Identifiers

PMID: 36039413
DOI: 10.21873/anticanres.15933

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