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Article

Polymorphism of the DNA base excision repair genes in keratoconus.

International journal of molecular sciences - 29 Oct 2014

Wojcik Katarzyna A, Synowiec Ewelina, Sobierajczyk Katarzyna, Izdebska Justyna, Blasiak Janusz, Szaflik Jerzy, Szaflik Jacek P

Abstract excerpt

Keratoconus (KC) is a degenerative corneal disorder for which the exact pathogenesis is not yet known. Oxidative stress is reported to be associated with this disease. The stress may damage corneal biomolecules, including DNA, and such damage is primarily removed by base excision repair (BER). Variation in genes encoding BER components may influence the effectiveness of corneal cells to cope with oxidative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25356504
DOI: 10.3390/ijms151119682
PMCID: PMC4264133

Genes

POLG
XRCC1
NEIL1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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