Article
Defective T cell activation and autoimmune disorder in Stra13-deficient mice.
Nature immunology - 1 Nov 2001
Sun H, Lu B, Li R Q, Flavell R A, Taneja R
Abstract excerpt
Stra13, a basic helix-loop-helix transcription factor, is up-regulated upon activation of CD4+ T cells. Here we show that Stra13-deficient mice exhibit defects in several phases of CD4+ T cell activation. In vivo, Stra13 deficiency results in ineffective elimination of activated T and B cells, which accumulate progressively, leading to lymphoid organ hyperplasia. Consequently, aging Stra13-/- mice develop...
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