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A family of unconventional deubiquitinases with modular chain specificity determinants

19 Feb 2018

Abstract excerpt

Deubiquitinating enzymes (DUBs) regulate ubiquitin signaling by trimming ubiquitin chains or removing ubiquitin from modified substrates. Similar activities exist for ubiquitin-related modifiers, although the enzymes involved are usually not related. Here, we report human ZUFSP (also known as ZUP1 and C6orf113) and fission yeast Mug105 as founding members of a DUB family different from the six known DUB classes....

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PMID: 29476094
DOI: 10.1038/s41467-018-03148-5

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