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Article

La FAM fatale: USP9X in development and disease

11 Feb 2015

Abstract excerpt

Deubiquitylating enzymes (DUBs), act downstream of ubiquitylation. As such, these post-post-translational modifiers function as the final arbitrators of a protein substrate's ubiquitylation status, thus regulating its fate. In most instances, DUBs moderate the absolute level of a substrate, its locality or activity, rather than being an "all-or-none" phenomenon. Yet, disruption of this quantitative regulation can...

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PMID: 25672900
DOI: 10.1007/s00018-015-1851-0

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