Article
Pathogenic tau species drive a psychosis-like phenotype in a mouse model of Alzheimer's disease.
Behavioural brain research - 15 Dec 2014
Koppel J, Jimenez H, Azose M, D'Abramo C, Acker C, Buthorn J, Greenwald B S, Lewis J, Lesser M, Liu Z, Davies P
Abstract excerpt
Psychotic Alzheimer's disease (AD+P) is a rapidly progressive variant of AD associated with an increased burden of frontal tau pathology that affects up to 50% of those with AD, and is observed more commonly in females. To date, there are no safe and effective medication interventions with an indication for treatment in this condition, and there has been only very limited exploration of potential animal models...
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