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Article

Dissecting Causal Pathways Using Mendelian Randomization with Summarized Genetic Data: Application to Age at Menarche and Risk of Breast Cancer.

Genetics - 1 Oct 2017

Burgess Stephen, Thompson Deborah J, Rees Jessica M B, Day Felix R, Perry John R, Ong Ken K

Abstract excerpt

Mendelian randomization is the use of genetic variants as instrumental variables to estimate causal effects of risk factors on outcomes. The total causal effect of a risk factor is the change in the outcome resulting from intervening on the risk factor. This total causal effect may potentially encompass multiple mediating mechanisms. For a proposed mediator, the direct effect of the risk factor is the change in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28835472
DOI: 10.1534/genetics.117.300191
PMCID: PMC5629317

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